Giorgio Grasselli

AulaWeb

AulaWeb 2023/24

Altre informazioni

Tel. (Lab): +39 010 8610 206
Alternative e-mail: giorgio.grasselli@iit
IIT Webpage: https://www.iit.it/it/people-details/-/people/giorgio-grasselli

APPLICATIONS for THESIS projects or as PRE-DOC or POSTDOC FELLOWS are welcome

RESEARCH TOPICS:

neuronal plasticity (structural and functional, at the synaptic level as well as looking at intrinsic excitability),
learning and memory
physiology and pathophysiology of the cerebellum
multiple sclerosis
cerebellar ataxia
autism
neuropsychiatric disorders

MAIN EXPERIMENTAL METHODS:

patch-clamp electrophysiology (in acute brain slices and primary neuronal cultures)
viral vectors for gene expression/silencing
immunohistochemistry
fluorescent/confocal microscopy and morphometric analysis

RELEVANT PUBLICATIONS:

Grasselli G, Boele HJ, Titley H, Bradford N, van Beers L, Jay L, Beekhof GC, Busch SE, De Zeeuw C, Schonewille M, Hansel C (2020) -SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces, PLoS Biol 18(1):e3000596, PMID: 31905212, DOI: 10.1371/journal.pbio.3000596
Grasselli G, He Q, Wan V, Adelman JP, Ohtsuki G, Hansel C (2016) - Activity-dependent plasticity of spike pauses in cerebellar Purkinje cells, Cell Rep 14(11):2546–2553, PMID: 26972012, DOI: 10.1016/j.celrep.2016.02.054
Grasselli G, Rossi S, Musella A, Gentile A, Loizzo S, Muzio L, Di Sanza C, Errico F, Musumeci G, Haji N, Fresegna D, Sepman H, De Chiara V, Furlan R, Martino G, Usiello A, Mandolesi G, Centonze D (2013) - Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis, Br J Pharmacol 168(2):502-17, PMID: 22924679, DOI: 10.1111/j.1476-5381.2012.02178.x
Mandolesi G, Grasselli G, Musella A, Sepman H, Musumeci G, Gentile A, Haji N, Fresegna D, Bernardi G, Centonze D (2012) - GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis, Neurobiol Dis 46(2):414-24 PMID: 22349452, DOI: 10.1016/j.nbd.2012.02.005
Grasselli G, Mandolesi G, Strata P and Cesare P (2011) – Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of GAP-43, PLoS One 6(6): e20791, PMID: 21695168, DOI: 10.1371/journal.pone.0020791