Giorgio Grasselli

Giorgio Grasselli
Giorgio Grasselli
Altre informazioni

Tel. (Lab): +39 010 8610 206 
Alternative e-mail: giorgio.grasselli@iit 
IIT Webpage:

APPLICATIONS for THESIS projects or as PRE-​DOC or POSTDOC FELLOWS are welcome


  • neuronal plasticity (structural and functional, at the synaptic level as well as looking at intrinsic excitability),
  • learning and memory
  • physiology and pathophysiology of the cerebellum 
  • multiple sclerosis
  • cerebellar ataxia
  • autism 
  • neuropsychiatric disorders 


  • patch-clamp electrophysiology (in acute brain slices and primary neuronal cultures)
  • viral vectors for gene expression/silencing
  • immunohistochemistry
  • fluorescent/confocal microscopy and morphometric analysis


  1. Grasselli G, Boele HJ, Titley H, Bradford N, van Beers L, Jay L, Beekhof GC, Busch SE, De Zeeuw C, Schonewille M, Hansel C  (2020) -SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces, PLoS Biol 18(1):e3000596, PMID: 31905212, DOI: 10.1371/journal.pbio.3000596
  2. Grasselli G, He Q, Wan V, Adelman JP, Ohtsuki G, Hansel C (2016) - Activity-dependent plasticity of spike pauses in cerebellar Purkinje cells, Cell Rep 14(11):2546–2553, PMID: 26972012, DOI: 10.1016/j.celrep.2016.02.054
  3. Grasselli G, Rossi S, Musella A, Gentile A, Loizzo S, Muzio L, Di Sanza C, Errico F, Musumeci G, Haji N, Fresegna D, Sepman H, De Chiara V, Furlan R, Martino G, Usiello A, Mandolesi G, Centonze D (2013) - Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis, Br J Pharmacol 168(2):502-17, PMID: 22924679, DOI: 10.1111/j.1476-5381.2012.02178.x
  4. Mandolesi G, Grasselli G, Musella A, Sepman H, Musumeci G, Gentile A, Haji N, Fresegna D, Bernardi G, Centonze D (2012) - GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis, Neurobiol Dis 46(2):414-24 PMID: 22349452, DOI: 10.1016/j.nbd.2012.02.005
  5. Grasselli G, Mandolesi G, Strata P and Cesare P (2011) – Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of GAP-43, PLoS One 6(6): e20791, PMID: 21695168, DOI: 10.1371/journal.pone.0020791 


ORCID (0000-0002-2942-9615):

Scopus (35573436500):

WoS (ResearcherID G-5094-2012):

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