Didattica

Insegnamenti

2025 - 2026

• FISIOLOGIA GENERALE (CTF) (cod. 111618)
  CORSO DI LAUREA MAGISTRALE (CICLO UNICO) - CHIMICA E TECNOLOGIA FARMACEUTICHE

2024 - 2025

• FISIOLOGIA GENERALE (CTF) (cod. 111618)
  CORSO DI LAUREA MAGISTRALE (CICLO UNICO) - CHIMICA E TECNOLOGIA FARMACEUTICHE

Ricerca

Pubblicazioni IRIS

• Modulation of neuronal excitability as an early therapeutic target to prevent neurodegeneration in EAE
  Anno: 2025
• Upregulation of the transcriptional repressor REST/NRSF as a protective mechanism against neuroinflammation in a mouse model of Multiple Sclerosis
  Anno: 2025
• The transcriptional repressor REST is protective against a mouse model of Multiple Sclerosis
  Anno: 2025
• Role of the transcriptional repressor REST/NRSF in the experimental autoimmune encephalomyelitis
  Anno: 2025
• Cerebellar climbing fibers repress spinogenesis locally on innervated dendritic branches in an activity-dependent manner
  Anno: 2024

Lista completa pubblicazioni IRIS

Altre informazioni

LABORATORY OF CEREBELLAR PHYSIOLOGY AND PATHOPHYSIOLOGY

LABORATORY OF CEREBELLAR PHYSIOLOGY AND PATHOPHYSIOLOGY

Group leader: Giorgio Grasselli

Location: Center for Synaptic Neuroscience and Technology (NSYN) of the Italian Institute of Technology at San Martino IRCCS Research Hospital

IIT Webpage: https://www.iit.it/it/web/guest/people-details/-/people/giorgio-grasselli

Tel. (Lab): +39 010 8610 206
Alternative e-mail: giorgio.grasselli@iit.it
 

APPLICATIONS for THESIS projects or as PRE-​DOC or POSTDOC FELLOWS are welcome

RESEARCH TOPICS: 

• neuronal plasticity (structural and functional, at the synaptic level as well as looking at intrinsic excitability),
• learning and memory
• physiology and pathophysiology of the cerebellum 
• multiple sclerosis
• cerebellar ataxia
• autism 
• neuropsychiatric disorders 

MAIN EXPERIMENTAL METHODS:

• patch-clamp electrophysiology (in acute brain slices and primary neuronal cultures)
• viral vectors for gene expression/silencing
• immunohistochemistry
• fluorescent/confocal microscopy and morphometric analysis
• mouse behavior

RELEVANT PUBLICATIONS:

1. Grasselli G, Boele HJ, Titley H, Bradford N, van Beers L, Jay L, Beekhof GC, Busch SE, De Zeeuw C, Schonewille M, Hansel C  (2020) -SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces, PLoS Biol 18(1):e3000596, PMID: 31905212, DOI: 10.1371/journal.pbio.3000596
2. Grasselli G, He Q, Wan V, Adelman JP, Ohtsuki G, Hansel C (2016) - Activity-dependent plasticity of spike pauses in cerebellar Purkinje cells, Cell Rep 14(11):2546–2553, PMID: 26972012, DOI: 10.1016/j.celrep.2016.02.054
3. Grasselli G, Rossi S, Musella A, Gentile A, Loizzo S, Muzio L, Di Sanza C, Errico F, Musumeci G, Haji N, Fresegna D, Sepman H, De Chiara V, Furlan R, Martino G, Usiello A, Mandolesi G, Centonze D (2013) - Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis, Br J Pharmacol 168(2):502-17, PMID: 22924679, DOI: 10.1111/j.1476-5381.2012.02178.x
4. Mandolesi G, Grasselli G, Musella A, Sepman H, Musumeci G, Gentile A, Haji N, Fresegna D, Bernardi G, Centonze D (2012) - GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis, Neurobiol Dis 46(2):414-24 PMID: 22349452, DOI: 10.1016/j.nbd.2012.02.005
5. Grasselli G, Mandolesi G, Strata P and Cesare P (2011) – Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of GAP-43, PLoS One 6(6): e20791, PMID: 21695168, DOI: 10.1371/journal.pone.0020791 
    

FULL UPDATED LIST OF PUBLICATIONS AVAILABLE HERE:

ORCID (0000-0002-2942-9615): https://orcid.org/0000-0002-2942-9615

Scopus (35573436500): https://www.scopus.com/authid/detail.uri?authorId=35573436500

WoS (ResearcherID G-5094-2012): https://www.webofscience.com/wos/author/record/G-5094-2012

Google Scholar: https://scholar.google.com/citations?user=DhuYSj8AAAAJ&hl=en

Pubmed: https://www.ncbi.nlm.nih.gov/myncbi/giorgio.grasselli.1/bibliography/public/