GIAMBATTISTA BONANNO PhD - Professor of Pharmacology
School of Medine and Pharmacy - Department of Pharmacy - University of Genoa (Italy) +390103532658 n e-mail: Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.
Education
1987: Ph. D. in Pharmacology and Toxicology; 1978: Degree in Pharmacy (honors); 1977: Degree in Chemistry and Pharmaceutical Technologies (honors)
Professional experience
2012-today: Director of the Dept. of Pharmacy, School of Medicine and Pharmacy University of Genoa, Italy; 2010-2012: Head of the Pharmacology and Toxicology Unit, Dept. of Pharmacy; 2009-2013: Member of the Directory of the Italian Society of Neuroscience, General Secretary and treasurer; 2007-today: Member of the Ethic Committee (Pediatric Section ) or the Liguria Region (Italy); 2002-today: Full Professor of Pharmacology; 1992-2002: Associate Professor; 1990-1992: Assistant Professor; 1988-1990: Postdoctoral Fellow; 1986-1987: Visiting Scientist, Inst. of Animal Physiology, Dept. of Neuro-endocrinology, Cambridge, UK; 1984: Visiting Scientist, Institute of Pharmacology, University of Freiburg, Germany; 1984-1987: PhD Student; 1979-1983: Research Fellow; 1775-1978: Internship Student.
Current research
Glutamate neurotransmission and excitotoxicity in ALS; influence of metabotropic glutamate receptors on neuron, astrocyte and microglia biochemistry and function in ALS; modification of glutamate and GABA release mechanisms under stressing conditions and after antidepressant drug treatment.
bibliometric indices
RELEVANT PUBLICATIONS (2010 – 2015)
Carney KE, Milanese M, van Nierop P, Li KW, Oliet SH, Smit AB, Bonanno G*, Verheijen MH*. Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins. J. Proteome Res. 13: 5918-5927 2014 *equally contributed
Stifanese R., Averna M., De Tullio M., Pedrazzi M., Milanese M., Bonifacino T., Bonanno G., Pontremoli S., Melloni E. Role of calpain-1 in the early phase of experimental ALS. Arch. Biochem. Biophys. 562: 1-8, 2014
Milanese M, Giribaldi F, Melone M, Bonifacino T, Musante I, Carminati E, Rossi P.I.A., Vergani L, Voci A, Conti F, Puliti A, Bonanno G. Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis. 64: 48-59, 2014
Giribaldi F., Milanese M., Bonifacino T., Rossi P.I.A., Di Prisco S., Pittaluga A., Tacchetti C., Puliti A., Usai C., Bonanno G. Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis. Neuropharmacology 56: 253-263, 2013
Uccelli A., Milanese M., Principato M.C., Morando S., Bonifacino T., Vergani L. , Giunti D., Voci A, Carminati E., Giribaldi F. , Caponnetto C., Bonanno G. Intravenous Mesenchymal Stem Cells Improve Survival and Motor Function in Experimental Amyotrophic Lateral Sclerosis. Mol. Med. 18: 794-804, 2012
Milanese M, Zappettini S. Onofri F, Musazzi L, Tardito D, Bonifacino T, Messa M, Racagni G, Usai C, Benfenati F, Popoli P, Bonanno G Abnormal exocytotic release of glutamate in a mouse model of amyotrophic lateral sclerosis. J Neurochem, 116: 1028-1042, 2011
Milanese M., Zappettini S., Jacchetti E., Bonifacino T., Cervetto C., Usai C., Bonanno G. In-vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophioc lateral sclerosis. J. Neurochem. 113: 489-501,2010
Stifanese R., Averna M., de tullio R., Pedrazzi M., Beccaria F., Salamino F., Milanese M., Bonanno G., Pontremoli S., Melloni E. Adaptative modifications in the calpain/calpastatin syatem in brain cells after persistent altration in Ca2+ homeostasis. J. Biol. Chem. 285: 631-643, 2010.
